THE RELATIONSHIPS BETWEEN PRE-PREGNANCY BODY MASS INDEX WITHHEPCIDIN AND FERITIN LEVELS

Abstract

Pregnancy with anemia is often occurs. An estimated 38% of pregnant women in the world are anemic.
Pregnant women who have a normal BMI before pregnancy have more iron stores. Being overweight, especially
obesity, is associated with systemic inflammation, thereby increasing hepcidin and ferritin, which disrupt
hemoglobin synthesis. This study aims to analyze the relationship between pre-pregnancy BMI with hepcidin
and ferritin levels. This research is an observational analytic study with a cross sectional approach. The
population is anemia pregnant women and the number of samples is 24 peoples. Blood collection, prepregnancy BMI data collection and hemoglobin level checks were carried out at Pauh Padang Health Center.
Hemoglobin levels were examined with a hematology analyzer. Hepcidin and ferritin were examined using the
ELISA method at the Biomedical Laboratory of Andalas University. The pre-pregnancy BMI variable was
divided into 2 categories, namely non-overweight (?24.99) and overweight (? 25.00). Data analysis was
performed by univariate and bivariate. The results showed that the mean hepcidin level in the overweight group
(39.70 ± 6.97 ng / ml) was higher than the mean hepcidin level in the non-overweight group (36.88 ± 5.83 ng/ml)
and the median ferritin level in the overweight group 17,33 (4.97-26.21) ng/ml was higher than the ferritin level
in the non-overweight group (5.49 (1.01-53.26) ng / ml). That showed no significant relationship between prepregnancy BMI and hepcidin levels (p = 0.69) and no significant relationship between pre-pregnancy BMI and
ferritin levels (p = 0.69).